Cell signalling in cancer Study guides, Class notes & Summaries

cell signalling (what key cellular processes can this regulate?) - the interchange of information between a cell + its environment, with the cell *giving precise responses to environmental signals*. - regulates all key processes, like CELLULAR GROWTH, PROLIFERATION, METABOLISM + SURVIVAL. Does the advancement of cancer involve genetic or epigenetic changes? - The advancement of cancer involves *genetic AND epigenetic changes!* - many common cancer genetic mutations involve SIGNALLING PROTE...

CPPS 325 FINAL EXAM WITH 100% CORRECT ANSWERS 2023/2024 Graded A+. What are the 5 well-known enzyme-linked cell surface receptors? - Correct Answer-1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific...

What are the 5 well-known enzyme-linked cell surface receptors? - 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residues on IC signalling molecules How are RTK and TK Ass...

CPPS EXAM PRACTICE QUESTIONS WITH CORRECT ANSWERS 2023/2024 (Graded). What isSH1 domain characterized by? - Correct Answer-Catalytic domain of a protein, for example the receptor. and it has the kinase activity. It is responsible for phosphorylating tyrosine residues. What is SH2 domain characterized by? - Correct Answer-Binds peptides with consensus (positional information on C-terminal side of the phosphorylated tyrosine). Very specific. Mediates protein-protein interactions in cellular ...

CPPS 325 FINAL EXAM 2023 rated A+What are the 5 well-known enzyme-linked cell surface receptors? - correct answer 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residues on IC s...

CPPS 325 FINAL EXAM graded A+ 2023 verifiedWhat are the 5 well-known enzyme-linked cell surface receptors? - correct answer 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residu...

CPPS 325 FINAL EXAM QUESTIONS WITH CORRECT ANSWERS 2023/2024 Graded A+. What is the only example of conformational change activation? - Correct Answer-Insulin receptor kinase. All other RTKs are activated through forms of dimerization. What are the two forms of dimerization? - Correct Answer-i) Receptors exist as unactivated dimers until ligand binds (Twist theory) ii) exist as monomers that are brought together and activated by ligand binding. What is the most common method of dimerizatio...

How targeted therapy and chemo differ -targeted therapies act on specific molecular targets on or within the cells that are associated with cancer, whereas standard chemo act on all rapidly dividing cells-chemo has more SEs-targeted therapy ae chosen and designed to interact with their target on or within the cells, whereas chemo were IDed becaused they kill cells-targeted therapies are often cytostatic (they block tumor cell proliferation) whereas chemo agents are cytotoxic (kill tumor cells) ...

CPPS 325 FINAL EXAM Questions and Answers 2023 What are the 5 well-known enzyme-linked cell surface receptors? 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residues on IC sign...

What are the 5 well-known enzyme-linked cell surface receptors? 1. Receptor Guanylyl Cyclase: produces cGMP 2. RTK: phosphorylate tyrosine residues leading to association of signalling molecules and cascade 3. TK Associated Receptors: associate with proteins having TK activity 4. Receptor Tyrosine Phosphates: Removes phosphate on tyrosine residues 5. Receptor Serine/Threonine Kinases: phosphorylate specific Serine/Threonine residues on IC signalling molecules How are RTK and TK Assoc...